Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration

HIGHLIGHTS: Compounds that interact with multiple targets but minimally with the cytochrome P450 system (CYP) address the many factors leading to neurodegeneration. Acetyl- and Butyryl-cholineEsterases (AChE, BChE) and Monoamine Oxidases A/B (MAO A, MAO B) are targets for Multi-Target Designed Ligan...

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Detalles Bibliográficos
Autores principales: Ramsay, Rona R., Majekova, Magdalena, Medina, Milagros, Valoti, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992697/
https://www.ncbi.nlm.nih.gov/pubmed/27597816
http://dx.doi.org/10.3389/fnins.2016.00375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992697/
https://www.ncbi.nlm.nih.gov/pubmed/27597816
http://dx.doi.org/10.3389/fnins.2016.00375

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