Efficacy of OZ439 (artefenomel) against early Plasmodium falciparum blood-stage malaria infection in healthy volunteers

OBJECTIVES: OZ439, or artefenomel, is an investigational synthetic ozonide antimalarial with similar potency, but a significantly improved pharmacokinetic profile, compared with artemisinins. We wished to measure key pharmacokinetic and pharmacodynamic parameters and the pharmacokinetic/pharmacodyna...

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Detalles Bibliográficos
Autores principales: McCarthy, James S., Baker, Mark, O'Rourke, Peter, Marquart, Louise, Griffin, Paul, Hooft van Huijsduijnen, Rob, Möhrle, Jörg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992851/
https://www.ncbi.nlm.nih.gov/pubmed/27272721
http://dx.doi.org/10.1093/jac/dkw174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992851/
https://www.ncbi.nlm.nih.gov/pubmed/27272721
http://dx.doi.org/10.1093/jac/dkw174

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