BDE47 induces rat CYP3A1 by targeting the transcriptional regulation of miR-23b

Cytochrome P450 3A (CYP3A) is the most abundant CYP450 enzyme in the liver and is involved in the metabolism of over 50% of xenobiotics. Our previous studies revealed that 2,2′,4,4′-tetrabromodiphenyl ether (BDE47) could induce rat CYP3A1 expression, but the molecular basis remains unclear. Using in...

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Detalles Bibliográficos
Autores principales: Sun, Zhenzhen, Zhang, Zhan, Ji, Minghui, Yang, Hongbao, Cromie, Meghan, Gu, Jun, Wang, Chao, Yang, Lu, Yu, Yongquan, Gao, Weimin, Wang, Shou-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992956/
https://www.ncbi.nlm.nih.gov/pubmed/27546062
http://dx.doi.org/10.1038/srep31958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992956/
https://www.ncbi.nlm.nih.gov/pubmed/27546062
http://dx.doi.org/10.1038/srep31958

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