Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents

BACKGROUND: The glyoxalase system including two thiol-dependent enzymes, glyoxalase I (Glo-I) and glyoxalase II, plays an important role in a ubiquitous metabolic pathway involved in cellular detoxification of cytotoxic 2-oxoaldehydes. Tumor cells have high glycolytic activity, leading to increased...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Balas, Qosay A, Hassan, Mohammad A, Al-Shar’i, Nizar A, Mhaidat, Nizar M, Almaaytah, Ammar M, Al-Mahasneh, Fatima M, Isawi, Israa H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993257/
https://www.ncbi.nlm.nih.gov/pubmed/27574401
http://dx.doi.org/10.2147/DDDT.S110997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993257/
https://www.ncbi.nlm.nih.gov/pubmed/27574401
http://dx.doi.org/10.2147/DDDT.S110997

Ejemplares similares