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Novel glyoxalase-I inhibitors possessing a “zinc-binding feature” as potential anticancer agents

BACKGROUND: The glyoxalase system including two thiol-dependent enzymes, glyoxalase I (Glo-I) and glyoxalase II, plays an important role in a ubiquitous metabolic pathway involved in cellular detoxification of cytotoxic 2-oxoaldehydes. Tumor cells have high glycolytic activity, leading to increased...

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Detalles Bibliográficos
Autores principales:	Al-Balas, Qosay A, Hassan, Mohammad A, Al-Shar’i, Nizar A, Mhaidat, Nizar M, Almaaytah, Ammar M, Al-Mahasneh, Fatima M, Isawi, Israa H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993257/ https://www.ncbi.nlm.nih.gov/pubmed/27574401 http://dx.doi.org/10.2147/DDDT.S110997

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