Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mic...

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Detalles Bibliográficos
Autores principales: Hall, Brandon M., Balan, Vitaly, Gleiberman, Anatoli S., Strom, Evguenia, Krasnov, Peter, Virtuoso, Lauren P., Rydkina, Elena, Vujcic, Slavoljub, Balan, Karina, Gitlin, Ilya, Leonova, Katerina, Polinsky, Alexander, Chernova, Olga B., Gudkov, Andrei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993332/
https://www.ncbi.nlm.nih.gov/pubmed/27391570
http://dx.doi.org/10.18632/aging.100991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993332/
https://www.ncbi.nlm.nih.gov/pubmed/27391570
http://dx.doi.org/10.18632/aging.100991

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