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Telomerase and estrogen-sensing activities are essential for continued mammary growth in vivo but dispensable for “reprogramming” neural stem cells

It has been proposed that the erosion of telomere length is a limiting factor in replicative capacity and important in cell senescence. To determine if this activity was essential in the mouse mammary gland in vivo, we serially transplanted mammary fragments from wild type (TER(+/+)), heterozygous (...

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Detalles Bibliográficos
Autores principales: George, Andrea L., Boulanger, Corinne A., Smith, Gilbert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993335/
https://www.ncbi.nlm.nih.gov/pubmed/27347776
http://dx.doi.org/10.18632/aging.100985