Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an important role in disease etiology. Recently, a DNA methylation based biomarker of tissue age has been advanced as...

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Detalles Bibliográficos
Autores principales: Horvath, Steve, Langfelder, Peter, Kwak, Seung, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F., Eszes, Marika, Faull, Richard L.M., Curtis, Maurice A., Waldvogel, Henry J., Choi, Oi-Wa, Tung, Spencer, Vinters, Harry V., Coppola, Giovanni, Yang, X. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993344/
https://www.ncbi.nlm.nih.gov/pubmed/27479945
http://dx.doi.org/10.18632/aging.101005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993344/
https://www.ncbi.nlm.nih.gov/pubmed/27479945
http://dx.doi.org/10.18632/aging.101005

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