Cargando…

Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels

Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an important role in disease etiology. Recently, a DNA methylation based biomarker of tissue age has been advanced as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Horvath, Steve, Langfelder, Peter, Kwak, Seung, Aaronson, Jeff, Rosinski, Jim, Vogt, Thomas F., Eszes, Marika, Faull, Richard L.M., Curtis, Maurice A., Waldvogel, Henry J., Choi, Oi-Wa, Tung, Spencer, Vinters, Harry V., Coppola, Giovanni, Yang, X. William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993344/ https://www.ncbi.nlm.nih.gov/pubmed/27479945 http://dx.doi.org/10.18632/aging.101005

Ejemplares similares

MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice
por: Langfelder, Peter, et al.
Publicado: (2018)

DNA methylation study of Huntington’s disease and motor progression in patients and in animal models
por: Lu, Ake T., et al.
Publicado: (2020)

Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington’s disease mice
por: Mégret, Lucile, et al.
Publicado: (2020)

The Role of Microglia and Astrocytes in Huntington’s Disease
por: Palpagama, Thulani H., et al.
Publicado: (2019)

Metabolic disruption identified in the Huntington’s disease transgenic sheep model
por: Handley, Renee. R., et al.
Publicado: (2016)

Network methods for describing sample relationships in genomic datasets: application to Huntington’s disease
por: Oldham, Michael C, et al.
Publicado: (2012)

Genetic cooperativity in multi-layer networks implicates cell survival and senescence in the striatum of Huntington’s disease mice synchronous to symptoms
por: Bigan, Erwan, et al.
Publicado: (2020)

Striatal parvalbuminergic neurons are lost in Huntington's disease: implications for dystonia
por: Reiner, Anton, et al.
Publicado: (2013)

Huntingtin Aggregates in the Olfactory Bulb in Huntington’s Disease
por: Highet, Blake, et al.
Publicado: (2020)

Current and Possible Future Therapeutic Options for Huntington’s Disease
por: Ferguson, Mackenzie W., et al.
Publicado: (2022)

Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets
por: Wang, James K. T., et al.
Publicado: (2017)

Disease-related Huntingtin seeding activities in cerebrospinal fluids of Huntington’s disease patients
por: Lee, C. Y. Daniel, et al.
Publicado: (2020)

The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression
por: Kwakowsky, Andrea, et al.
Publicado: (2020)

No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington’s disease
por: Huang, Ting-Ting, et al.
Publicado: (2020)

Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington's Disease and Parkinson's Disease Human Brains
por: Fourie, C., et al.
Publicado: (2014)

Cerebellar degeneration correlates with motor symptoms in Huntington disease
por: Singh‐Bains, Malvindar K., et al.
Publicado: (2019)

Therapeutic potential of alpha 5 subunit containing GABA(A) receptors in Alzheimer’s disease
por: Kwakowsky, Andrea, et al.
Publicado: (2021)

The cerebellum ages slowly according to the epigenetic clock
por: Horvath, Steve, et al.
Publicado: (2015)

Integrated genomics and proteomics to define huntingtin CAG length-dependent networks in HD Mice
por: Langfelder, Peter, et al.
Publicado: (2016)

iGluR expression in the hippocampal formation, entorhinal cortex, and superior temporal gyrus in Alzheimer’s disease
por: Yeung, Jason HY, et al.
Publicado: (2022)

Shape deformation analysis reveals the temporal dynamics of cell-type-specific homeostatic and pathogenic responses to mutant huntingtin
por: Megret, Lucile, et al.
Publicado: (2021)

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
por: Hegde, Ramanath Narayana, et al.
Publicado: (2020)

Making (anti-) sense out of huntingtin levels in Huntington disease
por: Evers, Melvin M, et al.
Publicado: (2015)

Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease
por: D’Souza, Gary X., et al.
Publicado: (2016)

Sleep Disorders and Circadian Disruption in Huntington’s Disease
por: Saade-Lemus, Sandra, et al.
Publicado: (2023)

Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
por: Marchionini, Deanna M., et al.
Publicado: (2022)

Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease
por: Mielcarek, Michal, et al.
Publicado: (2014)

A Multi-Omic Huntington’s Disease Transgenic Sheep-Model Database for Investigating Disease Pathogenesis
por: Mears, Emily R., et al.
Publicado: (2021)

Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease
por: Patassini, Stefano, et al.
Publicado: (2019)

Graded perturbations of metabolism in multiple regions of human brain in Alzheimer's disease: Snapshot of a pervasive metabolic disorder
por: Xu, Jingshu, et al.
Publicado: (2016)

Eigengene networks for studying the relationships between co-expression modules
por: Langfelder, Peter, et al.
Publicado: (2007)

WGCNA: an R package for weighted correlation network analysis
por: Langfelder, Peter, et al.
Publicado: (2008)

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates
por: Schut, Menno H., et al.
Publicado: (2017)

Transcriptional regulatory networks underlying gene expression changes in Huntington's disease
por: Ament, Seth A, et al.
Publicado: (2018)

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington’s Disease Neural Stem Cells
por: Ring, Karen L., et al.
Publicado: (2015)

Vascular Dysfunction in Alzheimer’s Disease: A Prelude to the Pathological Process or a Consequence of It?
por: Govindpani, Karan, et al.
Publicado: (2019)

When Is Hub Gene Selection Better than Standard Meta-Analysis?
por: Langfelder, Peter, et al.
Publicado: (2013)

Comparison of co-expression measures: mutual information, correlation, and model based indices
por: Song, Lin, et al.
Publicado: (2012)

Random generalized linear model: a highly accurate and interpretable ensemble predictor
por: Song, Lin, et al.
Publicado: (2013)

Do Disruptions in the Circadian Timing System Contribute to Autonomic Dysfunction in Huntington’s Disease?
por: Park, Saemi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eencp18ltfu1lamd8ld4agsm3r