Cargando…

Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier

Drug delivery into the brain is impeded by the blood-brain-barrier (BBB) that filters out the vast majority of drugs after systemic administration. In this work, we assessed the transport, uptake and cytotoxicity of promising drug nanocarriers, mesoporous silica nanoparticles (MSNs), in in vitro mod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baghirov, Habib, Karaman, Didem, Viitala, Tapani, Duchanoy, Alain, Lou, Yan-Ru, Mamaeva, Veronika, Pryazhnikov, Evgeny, Khiroug, Leonard, de Lange Davies, Catharina, Sahlgren, Cecilia, Rosenholm, Jessica M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993362/ https://www.ncbi.nlm.nih.gov/pubmed/27547955 http://dx.doi.org/10.1371/journal.pone.0160705

Ejemplares similares

Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles
por: Desai, Diti, et al.
Publicado: (2016)

Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home?
por: Paramonov, Valeriy M, et al.
Publicado: (2018)

Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections
por: Şen Karaman, Didem, et al.
Publicado: (2021)

Inkjet Printing of Drug-Loaded Mesoporous Silica Nanoparticles—A Platform for Drug Development
por: Wickström, Henrika, et al.
Publicado: (2017)

Chemical and photonic interactions in vitro and in vivo between fluorescent tracer and nanoparticle-based scavenger for enhanced molecular imaging
por: Gulin-Sarfraz, T., et al.
Publicado: (2019)

Dynamic visualization of membrane-inserted fraction of pHluorin-tagged channels using repetitive acidification technique
por: Khiroug, Serguei S, et al.
Publicado: (2009)

Polyethylenimine‐grafted mesoporous silica nanocarriers markedly enhance the bactericidal effect of curcumin against Staphylococcus aureus biofilm
por: Pamukçu, Ayşenur, et al.
Publicado: (2022)

Size, Stability, and Porosity of Mesoporous Nanoparticles Characterized with Light Scattering
por: Kaasalainen, Martti, et al.
Publicado: (2017)

Unusually Strong Temperature Dependence of P2X3 Receptor Traffic to the Plasma Membrane
por: Pryazhnikov, E., et al.
Publicado: (2011)

Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery
por: Slita, Anna, et al.
Publicado: (2018)

Dissociation Between Neuronal and Astrocytic Calcium Activity in Response to Locomotion in Mice
por: Fedotova, Anna, et al.
Publicado: (2023)

In vitro Targetability Validation of Peptide-Functionalized Mesoporous Silica Nanoparticles in the Presence of Serum Proteins
por: Paramonov, Valeriy M., et al.
Publicado: (2020)

Opposite Reactivity of Meningeal versus Cortical Microvessels to the Nitric Oxide Donor Glyceryl Trinitrate Evaluated In Vivo with Two-Photon Imaging
por: Pryazhnikov, Evgeny, et al.
Publicado: (2014)

Low micromolar Ba(2+) potentiates glutamate transporter current in hippocampal astrocytes
por: Afzalov, Ramil, et al.
Publicado: (2013)

Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles
por: Meka, Anand Kumar, et al.
Publicado: (2018)

Comparison of Polydopamine-Coated Mesoporous Silica Nanorods and Spheres for the Delivery of Hydrophilic and Hydrophobic Anticancer Drugs
por: Pada, Anna-Karin, et al.
Publicado: (2019)

Microfluidic-Assisted Fabrication of Dual-Coated pH-Sensitive Mesoporous Silica Nanoparticles for Protein Delivery
por: Küçüktürkmen, Berrin, et al.
Publicado: (2022)

Genetically-encoded tools for cAMP probing and modulation in living systems
por: Paramonov, Valeriy M., et al.
Publicado: (2015)

Feasibility Study of Mesoporous Silica Particles for Pulmonary Drug Delivery: Therapeutic Treatment with Dexamethasone in a Mouse Model of Airway Inflammation
por: Gulin-Sarfraz, Tina, et al.
Publicado: (2019)

Biosafety of Mesoporous Silica Nanoparticles
por: Rascol, Estelle, et al.
Publicado: (2018)

Mesoporous Silica Nanoparticles in Bioimaging
por: Yuan, Daohe, et al.
Publicado: (2020)

Shape engineering vs organic modification of inorganic nanoparticles as a tool for enhancing cellular internalization
por: Karaman, Didem Sen, et al.
Publicado: (2012)

Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery
por: Prabhakar, Neeraj, et al.
Publicado: (2016)

Effectiveness of Diverse Mesoporous Silica Nanoparticles as Potent Vehicles for the Drug L-DOPA
por: Swar, Sumita, et al.
Publicado: (2019)

Insights into the 3D permeable pore structure within novel monodisperse mesoporous silica nanoparticles by cryogenic electron tomography
por: Xia, Yidong, et al.
Publicado: (2023)

Pore Narrowing of Mesoporous Silica Materials
por: Goethals, Frederik, et al.
Publicado: (2013)

Synthesis of Polymer—Mesoporous Silica Nanocomposites
por: Wei, Liangming, et al.
Publicado: (2010)

Immobilization of Metronidazole on Mesoporous Silica Materials
por: Szentmihályi, Klára, et al.
Publicado: (2022)

Influence of spatial configurations on electromagnetic interference shielding of ordered mesoporous carbon/ordered mesoporous silica/silica composites
por: Wang, Jiacheng, et al.
Publicado: (2013)

Effects of mesoporous silica particle size and pore structure on the performance of polymer-mesoporous silica mixed matrix membranes
por: Wang, Junhui, et al.
Publicado: (2021)

Inhibiting Notch Activity in Breast Cancer Stem Cells by Glucose Functionalized Nanoparticles Carrying γ-secretase Inhibitors
por: Mamaeva, Veronika, et al.
Publicado: (2016)

Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures
por: Desai, Diti, et al.
Publicado: (2018)

Partitioning of Catechol Derivatives in Lipid Membranes: Implications for Substrate Specificity to Catechol-O-methyltransferase
por: Parkkila, Petteri, et al.
Publicado: (2020)

The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice
por: Lee, Soyoung, et al.
Publicado: (2013)

Cellular uptake and intracellular degradation of poly(alkyl cyanoacrylate) nanoparticles
por: Sulheim, Einar, et al.
Publicado: (2016)

Rational Design of Mesoporous Silica (SBA-15)/PF (Phenolic Resin) Nanocomposites by Tuning the Pore Sizes of Mesoporous Silica
por: Liu, Hongxia, et al.
Publicado: (2022)

Mesoporous Silica: A Suitable Adsorbent for Amines
por: Zamani, Cyrus, et al.
Publicado: (2009)

Gated Silica Mesoporous Materials in Sensing Applications
por: Sancenón, Félix, et al.
Publicado: (2015)

Mesoporous silica nanoparticles for drug and gene delivery
por: Zhou, Yixian, et al.
Publicado: (2018)

Mesoporous Silica Nanoparticles for Protein Protection and Delivery
por: Xu, Chun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jpbuencu3rnsj1nnvs0u273e26