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Evasion of cell senescence in SHH medulloblastoma
The mechanisms leading to brain tumor formation are poorly understood. Using Ptch1(+/−) mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution. Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type allele, an event a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993422/ https://www.ncbi.nlm.nih.gov/pubmed/27229128 http://dx.doi.org/10.1080/15384101.2016.1189044 |