IDH1/2 Mutants Inhibit TET-Promoted Oxidation of RNA 5mC to 5hmC

TETs (TET1/2/3) play critical roles in multi cellular processes through DNA demethylation driven by oxidation of DNA 5mdC to 5hmdC. Interestingly, recent studies indicated that TETs also oxidate RNA 5mC to 5hmC. However, little is known about the distribution of RNA 5hmC and the regulatory mechanism...

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Detalles Bibliográficos
Autores principales: Xu, Qiang, Wang, Kai, Wang, Lina, Zhu, Yuting, Zhou, Guangyu, Xie, Dan, Yang, Qingkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993491/
https://www.ncbi.nlm.nih.gov/pubmed/27548812
http://dx.doi.org/10.1371/journal.pone.0161261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993491/
https://www.ncbi.nlm.nih.gov/pubmed/27548812
http://dx.doi.org/10.1371/journal.pone.0161261

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