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Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations
The insulin-family proteins bind to their own receptors, but insulin-like growth factor II (IGF-II) can also bind to the A isoform of the insulin receptor (IR-A), activating unique and alternative signaling pathways from those of insulin. Although extensive studies of insulin have revealed that its...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993506/ https://www.ncbi.nlm.nih.gov/pubmed/27548502 http://dx.doi.org/10.1371/journal.pone.0161459 |