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Elucidating the Activation Mechanism of the Insulin-Family Proteins with Molecular Dynamics Simulations

The insulin-family proteins bind to their own receptors, but insulin-like growth factor II (IGF-II) can also bind to the A isoform of the insulin receptor (IR-A), activating unique and alternative signaling pathways from those of insulin. Although extensive studies of insulin have revealed that its...

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Detalles Bibliográficos
Autores principales:	Papaioannou, Anastasios, Kuyucak, Serdar, Kuncic, Zdenka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993506/ https://www.ncbi.nlm.nih.gov/pubmed/27548502 http://dx.doi.org/10.1371/journal.pone.0161459

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