BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein

BRCA2 is responsible for familial breast and ovarian cancer and has been linked to DNA repair and centrosome duplication. Here we analyzed the mechanism by which the centrosomal localization signal (CLS) of BRCA2 interacts with cytoplasmic dynein 1 to localize BRCA2 to the centrosome. In vitro pull-...

Descripción completa

Detalles Bibliográficos
Autores principales: Malik, Sadiya, Saito, Hiroko, Takaoka, Miho, Miki, Yoshio, Nakanishi, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993541/
https://www.ncbi.nlm.nih.gov/pubmed/27433848
http://dx.doi.org/10.1080/15384101.2016.1195531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993541/
https://www.ncbi.nlm.nih.gov/pubmed/27433848
http://dx.doi.org/10.1080/15384101.2016.1195531

Ejemplares similares