The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity

The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously, our lab has shown that ORF2p fragments containin...

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Detalles Bibliográficos
Autores principales: Christian, Claiborne M., Kines, Kristine J., Belancio, Victoria P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993571/
https://www.ncbi.nlm.nih.gov/pubmed/27583184
http://dx.doi.org/10.1080/2159256X.2016.1198300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993571/
https://www.ncbi.nlm.nih.gov/pubmed/27583184
http://dx.doi.org/10.1080/2159256X.2016.1198300

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