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The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity
The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously, our lab has shown that ORF2p fragments containin...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993571/ https://www.ncbi.nlm.nih.gov/pubmed/27583184 http://dx.doi.org/10.1080/2159256X.2016.1198300 |