Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition

Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular immortality. A significant fraction of tumors uses the alternative lengthening of telomeres (ALT) pathway to elongate their telomeres and to gain an unlimited proliferation potential. Since the ALT pathway is uniq...

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Detalles Bibliográficos
Autores principales: Deeg, Katharina I., Chung, Inn, Bauer, Caroline, Rippe, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993795/
https://www.ncbi.nlm.nih.gov/pubmed/27602331
http://dx.doi.org/10.3389/fonc.2016.00186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993795/
https://www.ncbi.nlm.nih.gov/pubmed/27602331
http://dx.doi.org/10.3389/fonc.2016.00186

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