Cargando…

Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma

It has been demonstrated that mTOR/p70S6K pathway was abnormally activated in many cancers and rapamycin and its analogs can restrain tumor growth through inhibiting this pathway, but some tumors including esophageal squamous cell carcinoma (ESCC) appear to be insensitive to rapamycin in recent stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Zhaoming, Peng, Kezheng, Wang, Ning, Liu, Hong-Min, Hou, Guiqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993948/ https://www.ncbi.nlm.nih.gov/pubmed/27595116 http://dx.doi.org/10.1155/2016/7828916

Ejemplares similares

Targeted Inhibition of mTOR Signaling Improves Sensitivity of Esophageal Squamous Cell Carcinoma Cells to Cisplatin
por: Hou, Guiqin, et al.
Publicado: (2014)

Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
por: Li, Jie, et al.
Publicado: (2019)

Inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by rapamycin
por: Wang, Xuerong, et al.
Publicado: (2017)

PSMD7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma via the mTOR/p70S6K pathway
por: Shi, Ke, et al.
Publicado: (2018)

Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma
por: Lu, Zhaoming, et al.
Publicado: (2021)

LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma
por: Hou, Guiqin, et al.
Publicado: (2019)

Downregulation of HOXA13 sensitizes human esophageal squamous cell carcinoma to chemotherapy
por: Shi, Qi, et al.
Publicado: (2018)

Dihydroartemisinin Inhibits the Proliferation of Esophageal Squamous Cell Carcinoma Partially by Targeting AKT1 and p70S6K
por: Zhu, Lili, et al.
Publicado: (2020)

Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice
por: Liu, Yao, et al.
Publicado: (2017)

Plumbagin Enhances the Anticancer Effects of PF Chemotherapy via Downregulation of the PI3K/AKT/mTOR/p70S6K Pathway in Human Tongue Squamous Cell Carcinoma
por: Pan, Shu-Ting, et al.
Publicado: (2023)

RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma
por: Lu, Zhaoming, et al.
Publicado: (2020)

The p70S6K/PI3K/MAPK feedback loop releases the inhibition effect of high-dose rapamycin on rat mesangial cell proliferation
por: Tian, Jihua, et al.
Publicado: (2021)

Assessing the efficacy of mammalian target of rapamycin inhibitors by phosphorylation of p70S6K in CD4-positive cells of liver transplant patients
por: Wang, Jun-Yu, et al.
Publicado: (2019)

Downregulation of H19 decreases the radioresistance in esophageal squamous cell carcinoma cells
por: Luo, Wenguang, et al.
Publicado: (2019)

Deletion and downregulation of MTAP contribute to the motility of esophageal squamous carcinoma cells
por: Cheng, Xiao-Yu, et al.
Publicado: (2017)

Downregulation of Ubiquitin Inhibits the Aggressive Phenotypes of Esophageal Squamous Cell Carcinoma
por: Gao, Yi, et al.
Publicado: (2020)

Hsp27 and Hsp70 Expression in Esophageal Squamous
por: Luz, Caio Cesar Floriano, et al.
Publicado: (2017)

Nestin expression involves invasiveness of esophageal carcinoma and its downregulation enhances paclitaxel sensitivity to esophageal carcinoma cell apoptosis
por: Zhang, Jinghang, et al.
Publicado: (2017)

Inhibition of mammalian target of rapamycin by rapamycin increases the radiosensitivity of esophageal carcinoma Eca109 cells
por: ZHANG, DEJUN, et al.
Publicado: (2014)

Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells
por: Kasioumi, Panagiota, et al.
Publicado: (2018)

Prognostic Significance of Periostin and Mammalian Target of Rapamycin (mTOR) in Locally Advanced Esophageal Squamous Cell Carcinoma
por: Jiang, Qi, et al.
Publicado: (2017)

RASSF8 downregulation promotes lymphangiogenesis and metastasis in esophageal squamous cell carcinoma
por: Zhang, Lan, et al.
Publicado: (2015)

MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma
por: Wang, Xintong, et al.
Publicado: (2019)

Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of rapamycin-p70S6 kinase in male rats
por: Liu, Shangjing, et al.
Publicado: (2017)

Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Carcinoma by Inhibiting IL-6 Signaling Pathway
por: Lu, Yao, et al.
Publicado: (2021)

Krüppel-Like Factor 4 Enhances Sensitivity of Cisplatin to Esophageal Squamous Cell Carcinoma (ESCC) Cells
por: Chen, Chuangui, et al.
Publicado: (2017)

Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma
por: Pawar, Harsh, et al.
Publicado: (2015)

Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma
por: Li, Fang, et al.
Publicado: (2018)

Downregulation of NONO induces apoptosis, suppressing growth and invasion in esophageal squamous cell carcinoma
por: Cheng, Rui, et al.
Publicado: (2018)

Suppression of Esophageal Squamous Cell Carcinoma Development by Mechanosensitive Protein Piezo1 Downregulation
por: Gao, Lu, et al.
Publicado: (2021)

p70S6K promotes IL-6-induced epithelial-mesenchymal transition and metastasis of head and neck squamous cell carcinoma
por: Wu, Dandan, et al.
Publicado: (2016)

Mammalian target of rapamycin and head and neck squamous cell carcinoma
por: Liao, Yu-Min, et al.
Publicado: (2011)

Redox-dependent modulation of metformin contributes to enhanced sensitivity of esophageal squamous cell carcinoma to cisplatin
por: Li, Pin Dong, et al.
Publicado: (2017)

MicroRNA-1 inhibits tumorigenicity of esophageal squamous cell carcinoma and enhances sensitivity to gefitinib
por: Yu, Qianqian, et al.
Publicado: (2018)

Copper transporter Ctr1 contributes to enhancement of the sensitivity of cisplatin in esophageal squamous cell carcinoma
por: Wang, Xin, et al.
Publicado: (2023)

Erratum: Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Carcinoma by Inhibiting IL-6 Signaling Pathway
Publicado: (2021)

Prognostic impact of LY6K and CDCA1 expression for patients with esophageal squamous cell carcinoma
por: Oguma, Junya, et al.
Publicado: (2020)

Raltitrexed increases radiation sensitivity of esophageal squamous carcinoma cells
por: Ding, Wen-Xiu, et al.
Publicado: (2019)

Downregulation of fibulin‐4 inhibits autophagy and promotes the sensitivity of esophageal squamous cell carcinoma cells to apatinib by activating the Akt‐mTOR signaling pathway
por: Chen, Xiangyu, et al.
Publicado: (2022)

PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma
por: Liu, Kang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_h96r4mbhf12vu2n7gdv4ba3dim