HIV-1 Vpr reactivates latent HIV-1 provirus by inducing depletion of class I HDACs on chromatin

HIV-1 Vpr is an accessory protein that induces proteasomal degradation of multiple proteins. We recently showed that Vpr targets class I HDACs on chromatin for proteasomal degradation. Here we show that Vpr induces degradation of HDAC1 and HDAC3 in HIV-1 latently infected J-Lat cells. Degradation of...

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Detalles Bibliográficos
Autores principales: Romani, Bizhan, Kamali Jamil, Razieh, Hamidi-Fard, Mojtaba, Rahimi, Pooneh, Momen, Seyed Bahman, Aghasadeghi, Mohammad Reza, Allahbakhshi, Elham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994036/
https://www.ncbi.nlm.nih.gov/pubmed/27550312
http://dx.doi.org/10.1038/srep31924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994036/
https://www.ncbi.nlm.nih.gov/pubmed/27550312
http://dx.doi.org/10.1038/srep31924

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