Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4

The nuclear pregnane X receptor (PXR) plays a central role in regulating xenobiotic metabolism. We now report a novel role for PXR as a critical negative regulator of innate immunity after infection. Pxr(−/−) mice exhibited remarkably elevated pro-inflammatory cytokine and chemokine production follo...

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Detalles Bibliográficos
Autores principales: Qiu, Zhijuan, Cervantes, Jorge L., Cicek, Basak B., Mukherjee, Subhajit, Venkatesh, Madhukumar, Maher, Leigh A., Salazar, Juan C., Mani, Sridhar, Khanna, Kamal M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994038/
https://www.ncbi.nlm.nih.gov/pubmed/27550658
http://dx.doi.org/10.1038/srep31936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994038/
https://www.ncbi.nlm.nih.gov/pubmed/27550658
http://dx.doi.org/10.1038/srep31936

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