Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

BACKGROUND: The fractalkine (CX3CR1) ligand is expressed in astrocytes and reported to be neuroprotective. When cleaved from the membrane, soluble fractalkine (sCX3CL1) activates the receptor CX3CR1. Although somewhat controversial, CX3CR1 is reported to be expressed in neurons and microglia. The me...

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Detalles Bibliográficos
Autores principales: O’Sullivan, Sinead A., Gasparini, Fabrizio, Mir, Anis K., Dev, Kumlesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994207/
https://www.ncbi.nlm.nih.gov/pubmed/27549131
http://dx.doi.org/10.1186/s12974-016-0659-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994207/
https://www.ncbi.nlm.nih.gov/pubmed/27549131
http://dx.doi.org/10.1186/s12974-016-0659-7

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