The effect of inhibiting glycinamide ribonucleotide formyl transferase on the development of neural tube in mice

BACKGROUND: Folate deficiency is closely related to the development of neural tube defects (NTDs). However, the exact mechanism is not completely understood. This study aims to induce murine NTDs by inhibiting one of the folate metabolic pathways, de novo purine synthesis and preliminarily investiga...

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Detalles Bibliográficos
Autores principales: Xu, Lin, Wang, Li, Wang, JianHua, Zhu, ZhiQiang, Chang, Ge, Guo, Ying, Tian, XinLi, Niu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994272/
https://www.ncbi.nlm.nih.gov/pubmed/27555878
http://dx.doi.org/10.1186/s12986-016-0114-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994272/
https://www.ncbi.nlm.nih.gov/pubmed/27555878
http://dx.doi.org/10.1186/s12986-016-0114-x

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