The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts

BACKGROUND: Colon and intestinal crypts serve as an important model system for adult stem cell proliferation and differentiation. We develop a spatial stochastic model to study the rate of somatic evolution in a normal crypt, focusing on the production of two-hit mutants that inactivate a tumor supp...

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Detalles Bibliográficos
Autores principales: Shahriyari, Leili, Komarova, Natalia L., Jilkine, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994304/
https://www.ncbi.nlm.nih.gov/pubmed/27549762
http://dx.doi.org/10.1186/s13062-016-0141-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994304/
https://www.ncbi.nlm.nih.gov/pubmed/27549762
http://dx.doi.org/10.1186/s13062-016-0141-6

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