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Tumor Induced Stromal Reprogramming Drives Lymph Node Transformation
Lymph node (LN) stromal cells, particularly fibroblastic reticular cells (FRCs), provide critical structural support and regulate immunity, tolerance and transport properties of LNs. In many tumors, LN metastasis is predictive of poor prognosis. However, the stromal contribution to the evolving micr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994871/ https://www.ncbi.nlm.nih.gov/pubmed/27400148 http://dx.doi.org/10.1038/ni.3492 |