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Tumor Induced Stromal Reprogramming Drives Lymph Node Transformation

Lymph node (LN) stromal cells, particularly fibroblastic reticular cells (FRCs), provide critical structural support and regulate immunity, tolerance and transport properties of LNs. In many tumors, LN metastasis is predictive of poor prognosis. However, the stromal contribution to the evolving micr...

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Detalles Bibliográficos
Autores principales: Riedel, Angela, Shorthouse, David, Haas, Lisa, Hall, Benjamin A, Shields, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994871/
https://www.ncbi.nlm.nih.gov/pubmed/27400148
http://dx.doi.org/10.1038/ni.3492