Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions. Rational genetic engineering for the production of natural product derivatives is desirab...

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Detalles Bibliográficos
Autores principales: Nielsen, Maria Lund, Isbrandt, Thomas, Petersen, Lene Maj, Mortensen, Uffe Hasbro, Andersen, Mikael Rørdam, Hoof, Jakob Blæsbjerg, Larsen, Thomas Ostenfeld
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994942/
https://www.ncbi.nlm.nih.gov/pubmed/27551732
http://dx.doi.org/10.1371/journal.pone.0161199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994942/
https://www.ncbi.nlm.nih.gov/pubmed/27551732
http://dx.doi.org/10.1371/journal.pone.0161199

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