Cargando…

Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering

Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions. Rational genetic engineering for the production of natural product derivatives is desirab...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nielsen, Maria Lund, Isbrandt, Thomas, Petersen, Lene Maj, Mortensen, Uffe Hasbro, Andersen, Mikael Rørdam, Hoof, Jakob Blæsbjerg, Larsen, Thomas Ostenfeld
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994942/ https://www.ncbi.nlm.nih.gov/pubmed/27551732 http://dx.doi.org/10.1371/journal.pone.0161199

Ejemplares similares

Genes Linked to Production of Secondary Metabolites in Talaromyces atroroseus Revealed Using CRISPR-Cas9
por: Nielsen, Maria Lund, et al.
Publicado: (2017)

Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
por: Theobald, Sebastian, et al.
Publicado: (2019)

Aspergillus nidulans Synthesize Insect Juvenile Hormones upon Expression of a Heterologous Regulatory Protein and in Response to Grazing by Drosophila melanogaster Larvae
por: Nielsen, Morten Thrane, et al.
Publicado: (2013)

Heterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach
por: Nielsen, Morten Thrane, et al.
Publicado: (2013)

Correction: Heterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach
por: Nielsen, Morten Thrane, et al.
Publicado: (2013)

Antimicrobial potential of Actinomycetes by NRPS and PKS-I pathways
por: Hernández- Macedo, Maria Lucila, et al.
Publicado: (2014)

ClusterMine360: a database of microbial PKS/NRPS biosynthesis
por: Conway, Kyle R., et al.
Publicado: (2013)

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
por: Awakawa, Takayoshi, et al.
Publicado: (2018)

Identification of PKS-NRPS Hybrid Metabolites in Marine-Derived Penicillium oxalicum
por: Li, Hongcheng, et al.
Publicado: (2022)

A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin
por: Zhang, Hongjiao, et al.
Publicado: (2022)

Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS–PKS hybrid enzyme
por: Yun, Choong-Soo, et al.
Publicado: (2015)

A Versatile System for USER Cloning-Based Assembly of Expression Vectors for Mammalian Cell Engineering
por: Lund, Anne Mathilde, et al.
Publicado: (2014)

Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication
por: Theobald, Sebastian, et al.
Publicado: (2018)

Bioactive PKS–NRPS Alkaloids from the Plant-Derived Endophytic Fungus Xylaria arbuscula
por: Wang, Ya, et al.
Publicado: (2021)

Epilithic Biofilms in Lake Baikal: Screening and Diversity of PKS and NRPS Genes in the Genomes of Heterotrophic Bacteria
por: SUKHANOVA, ELENA, et al.
Publicado: (2018)

Variations of Indole Metabolites and NRPS-PKS Loci in Two Different Virulent Strains of Xenorhabdus hominickii
por: Mollah, Md. Mahi Imam, et al.
Publicado: (2020)

Taxogenomic and Comparative Genomic Analysis of the Genus Saccharomonospora Focused on the Identification of Biosynthetic Clusters PKS and NRPS
por: Ramírez-Durán, Ninfa, et al.
Publicado: (2021)

Bioinformatic and Mechanistic Analysis of the Palmerolide PKS-NRPS Biosynthetic Pathway From the Microbiome of an Antarctic Ascidian
por: Avalon, Nicole E., et al.
Publicado: (2021)

Designing and Implementing an Assay for the Detection of Rare and Divergent NRPS and PKS Clones in European, Antarctic and Cuban Soils
por: Amos, Gregory C. A., et al.
Publicado: (2015)

Characterization of NRPS and PKS genes involved in the biosynthesis of SMs in Alternaria dauci including the phytotoxic polyketide aldaulactone
por: Courtial, Julia, et al.
Publicado: (2022)

Allopeptimicins: unique antibacterial metabolites generated by hybrid PKS-NRPS, with original self-defense mechanism in Actinoallomurus
por: Iorio, Marianna, et al.
Publicado: (2022)

Optimization of Degenerate PCR Conditions for Reducing Error Rates in Detection of PKS and NRPS Gene groups in Actinomycetes
por: Ghashghaei, Sara, et al.
Publicado: (2023)

Genome Mining Uncovers NRPS and PKS Clusters in Rothia dentocariosa with Inhibitory Activity against Neisseria Species
por: Akomoneh, Elvis Achondou, et al.
Publicado: (2023)

A Hybrid NRPS-PKS Gene Cluster Related to the Bleomycin Family of Antitumor Antibiotics in Alteromonas macleodii Strains
por: Mizuno, Carolina Megumi, et al.
Publicado: (2013)

Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata
por: Zhang, Chen, et al.
Publicado: (2017)

The Mosaic Architecture of NRPS-PKS in the Arbuscular Mycorrhizal Fungus Gigaspora margarita Shows a Domain With Bacterial Signature
por: Venice, Francesco, et al.
Publicado: (2020)

In Silico Analysis of PKS and NRPS Gene Clusters in Arisostatin- and Kosinostatin-Producers and Description of Micromonospora okii sp. nov.
por: Komaki, Hisayuki, et al.
Publicado: (2021)

Classification of the Adenylation and Acyl-Transferase Activity of NRPS and PKS Systems Using Ensembles of Substrate Specific Hidden Markov Models
por: Khayatt, Barzan I., et al.
Publicado: (2013)

Metagenomic Analysis of Upwelling-Affected Brazilian Coastal Seawater Reveals Sequence Domains of Type I PKS and Modular NRPS
por: Cuadrat, Rafael R. C., et al.
Publicado: (2015)

Isolation and Biosynthetic Analysis of Haliamide, a New PKS-NRPS Hybrid Metabolite from the Marine Myxobacterium Haliangium ochraceum
por: Sun, Yuwei, et al.
Publicado: (2016)

Tricholides A and B and Unnarmicin D: New Hybrid PKS-NRPS Macrocycles Isolated from an Environmental Collection of Trichodesmium thiebautii
por: Bertin, Matthew J., et al.
Publicado: (2017)

SeMPI 2.0—A Web Server for PKS and NRPS Predictions Combined with Metabolite Screening in Natural Product Databases
por: Zierep, Paul F., et al.
Publicado: (2020)

Mining and characterization of the PKS–NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996
por: Zhang, Tao, et al.
Publicado: (2022)

A Versatile in Vivo DNA Assembly Toolbox for Fungal Strain Engineering
por: Jarczynska, Zofia Dorota, et al.
Publicado: (2022)

Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility
por: Subko, Karolina, et al.
Publicado: (2021)

Bioactivity and Metabolome Mining of Deep-Sea Sediment-Derived Microorganisms Reveal New Hybrid PKS-NRPS Macrolactone from Aspergillus versicolor PS108-62
por: Magot, Florent, et al.
Publicado: (2023)

Full-length title: NRPPUR database search and in vitro analysis identify an NRPS-PKS biosynthetic gene cluster with a potential antibiotic effect
por: Fritz, Shirley, et al.
Publicado: (2018)

A Single Sfp-Type Phosphopantetheinyl Transferase Plays a Major Role in the Biosynthesis of PKS and NRPS Derived Metabolites in Streptomyces ambofaciens ATCC23877
por: Bunet, Robert, et al.
Publicado: (2014)

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
por: Rausch, Christian, et al.
Publicado: (2007)

A PKS/NRPS/FAS Hybrid Gene Cluster from Serratia plymuthica RVH1 Encoding the Biosynthesis of Three Broad Spectrum, Zeamine-Related Antibiotics
por: Masschelein, Joleen, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_pu6er1is4rgei73sctjpnq2j7p