The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila

RAS-induced MAPK signaling is a central driver of the cell proliferation apparatus. Disruption of this pathway is widely observed in cancer and other pathologies. Consequently, considerable effort has been devoted to understanding the mechanistic aspects of RAS-MAPK signal transmission and regulatio...

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Detalles Bibliográficos
Autores principales: Ashton-Beaucage, Dariel, Lemieux, Caroline, Udell, Christian M., Sahmi, Malha, Rochette, Samuel, Therrien, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994957/
https://www.ncbi.nlm.nih.gov/pubmed/27552662
http://dx.doi.org/10.1371/journal.pbio.1002539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994957/
https://www.ncbi.nlm.nih.gov/pubmed/27552662
http://dx.doi.org/10.1371/journal.pbio.1002539

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