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Ligand Binding at the α4-α4 Agonist-Binding Site of the α4β2 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State
The α4β2 nicotinic acetylcholine receptor (nAChR) is the most abundant subtype in the brain and exists in two functional stoichiometries: (α4)(3)(β2)(2) and (α4)(2)(β2)(3). A distinct feature of the (α4)(3)(β2)(2) receptor is the biphasic activation response to the endogenous agonist acetylcholine,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995024/ https://www.ncbi.nlm.nih.gov/pubmed/27552221 http://dx.doi.org/10.1371/journal.pone.0161154 |