Blimp-1–mediated CD4 T cell exhaustion causes CD8 T cell dysfunction during chronic toxoplasmosis

CD8, but not CD4, T cells are considered critical for control of chronic toxoplasmosis. Although CD8 exhaustion has been previously reported in Toxoplasma encephalitis (TE)–susceptible model, our current work demonstrates that CD4 not only become exhausted during chronic toxoplasmosis but this dysfu...

Descripción completa

Detalles Bibliográficos
Autores principales: Hwang, SuJin, Cobb, Dustin A., Bhadra, Rajarshi, Youngblood, Ben, Khan, Imtiaz A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995081/
https://www.ncbi.nlm.nih.gov/pubmed/27481131
http://dx.doi.org/10.1084/jem.20151995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995081/
https://www.ncbi.nlm.nih.gov/pubmed/27481131
http://dx.doi.org/10.1084/jem.20151995

Ejemplares similares