Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development

T cell antigen receptor δ (Tcrd) variable region exons are assembled by RAG-initiated V(D)J recombination events in developing γδ thymocytes. Here, we use linear amplification–mediated high-throughput genome-wide translocation sequencing (LAM-HTGTS) to map hundreds of thousands of RAG-initiated Tcrd...

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Detalles Bibliográficos
Autores principales: Zhao, Lijuan, Frock, Richard L., Du, Zhou, Hu, Jiazhi, Chen, Liang, Krangel, Michael S., Alt, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995090/
https://www.ncbi.nlm.nih.gov/pubmed/27526713
http://dx.doi.org/10.1084/jem.20160670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995090/
https://www.ncbi.nlm.nih.gov/pubmed/27526713
http://dx.doi.org/10.1084/jem.20160670

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