Cargando…

Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio

Collaboration among the multitude of RNA-binding proteins (RBPs) is ubiquitous, yet our understanding of these key regulatory complexes has been limited to single RBPs. We investigated combinatorial translational regulation by Drosophila Pumilio (Pum) and Nanos (Nos), which control development, fert...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weidmann, Chase A, Qiu, Chen, Arvola, René M, Lou, Tzu-Fang, Killingsworth, Jordan, Campbell, Zachary T, Tanaka Hall, Traci M, Goldstrohm, Aaron C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995099/ https://www.ncbi.nlm.nih.gov/pubmed/27482653 http://dx.doi.org/10.7554/eLife.17096

Ejemplares similares

Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins
por: Arvola, René M., et al.
Publicado: (2017)

A conserved domain of Drosophila RNA-binding protein Pumilio interacts with multiple CCR4–NOT deadenylase complex subunits to repress target mRNAs
por: Haugen, Rebecca J., et al.
Publicado: (2022)

Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs
por: Arvola, René M, et al.
Publicado: (2020)

The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation
por: Weidmann, Chase A., et al.
Publicado: (2014)

Regulation of the Drosophila transcriptome by Pumilio and CCR4-NOT deadenylase
por: Haugen, Rebecca J., et al.
Publicado: (2023)

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA
por: Groothuizen, Flora S, et al.
Publicado: (2015)

Molecular architecture of human polycomb repressive complex 2
por: Ciferri, Claudio, et al.
Publicado: (2012)

cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ
por: Fernandez-Leiro, Rafael, et al.
Publicado: (2015)

Proteins acting out of (dis)order
por: Eliezer, David
Publicado: (2017)

Nucleotide inhibition of the pancreatic ATP-sensitive K(+) channel explored with patch-clamp fluorometry
por: Usher, Samuel G, et al.
Publicado: (2020)

Multistep loading of a DNA sliding clamp onto DNA by replication factor C
por: Schrecker, Marina, et al.
Publicado: (2022)

No significant regulation of bicoid mRNA by Pumilio or Nanos in the early Drosophila embryo
por: Wharton, Tammy H., et al.
Publicado: (2018)

Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
por: Subramanian, Subu, et al.
Publicado: (2021)

A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA
por: Liu, Xingchen, et al.
Publicado: (2022)

Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo
por: Bothma, Jacques P, et al.
Publicado: (2015)

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader
por: Gaubitz, Christl, et al.
Publicado: (2022)

Identification of Synaptic Targets of Drosophila Pumilio
por: Chen, Gengxin, et al.
Publicado: (2008)

Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization
por: Andriani, Rizki Tsari, et al.
Publicado: (2021)

The molecular basis for ANE syndrome revealed by the large ribosomal subunit processome interactome
por: McCann, Kathleen L, et al.
Publicado: (2016)

Subdued, a TMEM16 family Ca(2+)-activated Cl(−) channel in Drosophila melanogaster with an unexpected role in host defense
por: Wong, Xiu Ming, et al.
Publicado: (2013)

Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins
por: Bohn, Jennifer A, et al.
Publicado: (2018)

Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila
por: Tikhonova, Evgeniya, et al.
Publicado: (2022)

Transmembrane protein CD69 acts as an S1PR1 agonist
por: Chen, Hongwen, et al.
Publicado: (2023)

Fatty acid analogue N-arachidonoyl taurine restores function of I(Ks) channels with diverse long QT mutations
por: Liin, Sara I, et al.
Publicado: (2016)

Cryo-EM structures of mitochondrial respiratory complex I from Drosophila melanogaster
por: Agip, Ahmed-Noor A, et al.
Publicado: (2023)

The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies
por: Cottee, Matthew A, et al.
Publicado: (2015)

Mapping translation 'hot-spots' in live cells by tracking single molecules of mRNA and ribosomes
por: Katz, Zachary B, et al.
Publicado: (2016)

An unexpected INAD PDZ tandem-mediated plcβ binding in Drosophila photo receptors
por: Ye, Fei, et al.
Publicado: (2018)

Domain–domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel
por: Zaydman, Mark A, et al.
Publicado: (2014)

Resting mitochondrial complex I from Drosophila melanogaster adopts a helix-locked state
por: Padavannil, Abhilash, et al.
Publicado: (2023)

Negative Regulation of EGFR/MAPK Pathway by Pumilio in Drosophila melanogaster
por: Kim, Sung Yun, et al.
Publicado: (2012)

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly
por: Cottee, Matthew A, et al.
Publicado: (2013)

A K(+)-selective CNG channel orchestrates Ca(2+) signalling in zebrafish sperm
por: Fechner, Sylvia, et al.
Publicado: (2015)

Selection of chromosomal DNA libraries using a multiplex CRISPR system
por: Ryan, Owen W, et al.
Publicado: (2014)

An internal thioester in a pathogen surface protein mediates covalent host binding
por: Walden, Miriam, et al.
Publicado: (2015)

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network
por: Nwachukwu, Jerome C, et al.
Publicado: (2014)

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone
por: Padavannil, Abhilash, et al.
Publicado: (2019)

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome
por: Enwerem, Isioma I.I., et al.
Publicado: (2021)

The Eaf3 chromodomain acts as a pH sensor for gene expression by altering its binding affinity for histone methylated-lysine residues
por: Okuda, Masahiko, et al.
Publicado: (2020)

Pumilio2 regulates synaptic plasticity via translational repression of synaptic receptors in mice
por: Dong, Hongxin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_79gp55nplsp0iptcf4btc4j4qr