Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance

Zinc transporter 8 (ZnT8), encoded by SLC30A8, is chiefly expressed within pancreatic islet cells, where it mediates zinc (Zn(2+)) uptake into secretory granules. Although a common nonsynonymous polymorphism (R325W), which lowers activity, is associated with increased type 2 diabetes (T2D) risk, rar...

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Detalles Bibliográficos
Autores principales: Mitchell, Ryan K., Hu, Ming, Chabosseau, Pauline L., Cane, Matthew C., Meur, Gargi, Bellomo, Elisa A., Carzaniga, Raffaella, Collinson, Lucy M., Li, Wen-Hong, Hodson, David J., Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995240/
https://www.ncbi.nlm.nih.gov/pubmed/26584158
http://dx.doi.org/10.1210/me.2015-1227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995240/
https://www.ncbi.nlm.nih.gov/pubmed/26584158
http://dx.doi.org/10.1210/me.2015-1227

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