Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner

BACKGROUND AND PURPOSE: Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness (AHR). Although the molecular mechanisms remain unclear, activation of specific PI3K isoforms mediate inflammation and AHR. We aimed to determine whether inh...

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Detalles Bibliográficos
Autores principales: Koziol‐White, Cynthia J, Yoo, Edwin J, Cao, Gaoyuan, Zhang, Jie, Papanikolaou, Eleni, Pushkarsky, Ivan, Andrews, Adam, Himes, Blanca E, Damoiseaux, Robert D, Liggett, Stephen B, Di Carlo, Dino, Kurten, Richard C, Panettieri, Reynold A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995285/
https://www.ncbi.nlm.nih.gov/pubmed/27352269
http://dx.doi.org/10.1111/bph.13542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995285/
https://www.ncbi.nlm.nih.gov/pubmed/27352269
http://dx.doi.org/10.1111/bph.13542

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