An Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal Model

Huntington's disease (HD) is a fatal progressive disease linked to expansion of glutamine repeats in the huntingtin protein and characterized by the progressive loss of cognitive and motor function. We show that expression of a mutant human huntingtin exon-1-GFP fusion construct results in nons...

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Detalles Bibliográficos
Autores principales: Amaro, I. Alexandra, Henderson, Lee A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995342/
https://www.ncbi.nlm.nih.gov/pubmed/27595037
http://dx.doi.org/10.1155/2016/7120753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995342/
https://www.ncbi.nlm.nih.gov/pubmed/27595037
http://dx.doi.org/10.1155/2016/7120753

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