HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

BACKGROUND: The blood-brain barrier (BBB) dysfunction represents an early feature of Alzheimer’s disease (AD) that precedes the hallmarks of amyloid beta (amyloid β) plaque deposition and neuronal neurofibrillary tangle (NFT) formation. A damaged BBB correlates directly with neuroinflammation involv...

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Detalles Bibliográficos
Autores principales: Festoff, Barry W., Sajja, Ravi K., van Dreden, Patrick, Cucullo, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995775/
https://www.ncbi.nlm.nih.gov/pubmed/27553758
http://dx.doi.org/10.1186/s12974-016-0670-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995775/
https://www.ncbi.nlm.nih.gov/pubmed/27553758
http://dx.doi.org/10.1186/s12974-016-0670-z

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