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HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

BACKGROUND: The blood-brain barrier (BBB) dysfunction represents an early feature of Alzheimer’s disease (AD) that precedes the hallmarks of amyloid beta (amyloid β) plaque deposition and neuronal neurofibrillary tangle (NFT) formation. A damaged BBB correlates directly with neuroinflammation involv...

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Detalles Bibliográficos
Autores principales:	Festoff, Barry W., Sajja, Ravi K., van Dreden, Patrick, Cucullo, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995775/ https://www.ncbi.nlm.nih.gov/pubmed/27553758 http://dx.doi.org/10.1186/s12974-016-0670-z

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