A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M

The Mcm2-7 complex is the catalytic core of the eukaryotic replicative helicase. Here, we identify a new role for this complex in maintaining genome integrity. Using both genetic and cytological approaches, we find that a specific mcm allele (mcm2DENQ) causes elevated genome instability that correla...

Descripción completa

Detalles Bibliográficos
Autores principales: Vijayraghavan, Sriram, Tsai, Feng-Ling, Schwacha, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996524/
https://www.ncbi.nlm.nih.gov/pubmed/27556397
http://dx.doi.org/10.1371/journal.pgen.1006277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996524/
https://www.ncbi.nlm.nih.gov/pubmed/27556397
http://dx.doi.org/10.1371/journal.pgen.1006277

Ejemplares similares