Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography

Archaeal replicative DNA polymerase D (PolD) constitute an atypical class of DNA polymerases made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2), both with unknown structures. We have determined the crystal structures of Pyrococcus abyssi DP1 and DP2 at 2...

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Detalles Bibliográficos
Autores principales: Sauguet, Ludovic, Raia, Pierre, Henneke, Ghislaine, Delarue, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996933/
https://www.ncbi.nlm.nih.gov/pubmed/27548043
http://dx.doi.org/10.1038/ncomms12227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996933/
https://www.ncbi.nlm.nih.gov/pubmed/27548043
http://dx.doi.org/10.1038/ncomms12227

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