Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding

The post-translational modification S-sulfenylation functions as a key sensor of oxidative stress. Yet the dynamics of sulfenic acid in proteins remains largely elusive due to its fleeting nature. Here we use single-molecule force-clamp spectroscopy and mass spectrometry to directly capture the reac...

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Detalles Bibliográficos
Autores principales: Beedle, Amy E. M., Lynham, Steven, Garcia-Manyes, Sergi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996944/
https://www.ncbi.nlm.nih.gov/pubmed/27546612
http://dx.doi.org/10.1038/ncomms12490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996944/
https://www.ncbi.nlm.nih.gov/pubmed/27546612
http://dx.doi.org/10.1038/ncomms12490

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