Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

Studies in knockout mice provide evidence that MSH2–MSH3 and the BER machinery promote trinucleotide repeat (TNR) expansion, yet how these two different repair pathways cause the mutation is unknown. Here we report the first molecular crosstalk mechanism, in which MSH2–MSH3 is used as a component of...

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Detalles Bibliográficos
Autores principales: Lai, Yanhao, Budworth, Helen, Beaver, Jill M., Chan, Nelson L. S., Zhang, Zunzhen, McMurray, Cynthia T., Liu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996945/
https://www.ncbi.nlm.nih.gov/pubmed/27546332
http://dx.doi.org/10.1038/ncomms12465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996945/
https://www.ncbi.nlm.nih.gov/pubmed/27546332
http://dx.doi.org/10.1038/ncomms12465

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