Cargando…

Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

Studies in knockout mice provide evidence that MSH2–MSH3 and the BER machinery promote trinucleotide repeat (TNR) expansion, yet how these two different repair pathways cause the mutation is unknown. Here we report the first molecular crosstalk mechanism, in which MSH2–MSH3 is used as a component of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lai, Yanhao, Budworth, Helen, Beaver, Jill M., Chan, Nelson L. S., Zhang, Zunzhen, McMurray, Cynthia T., Liu, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996945/ https://www.ncbi.nlm.nih.gov/pubmed/27546332 http://dx.doi.org/10.1038/ncomms12465

Ejemplares similares

Base excision repair of oxidative DNA damage coupled with removal of a CAG repeat hairpin attenuates trinucleotide repeat expansion
por: Xu, Meng, et al.
Publicado: (2014)

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair
por: Beaver, Jill M., et al.
Publicado: (2015)

An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract
por: Beaver, Jill M., et al.
Publicado: (2018)

Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6
por: Pal, Arumay, et al.
Publicado: (2020)

Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
por: Wiesendanger, Margrit, et al.
Publicado: (2000)

Problems and solutions for the analysis of somatic CAG repeat expansion and their relationship to Huntington's disease toxicity
por: Budworth, Helen, et al.
Publicado: (2016)

Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia
por: Lai, Yanhao, et al.
Publicado: (2014)

The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions
por: Richard, Guy-Franck
Publicado: (2021)

Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2–MSH6 complex
por: Banerjee, Sreeparna, et al.
Publicado: (2005)

Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2–MSH6 complex
por: Banerjee, Sreeparna, et al.
Publicado: (2005)

Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair
por: DuPrie, Matthew L., et al.
Publicado: (2022)

Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response
por: Vasilyeva, Aksana, et al.
Publicado: (2010)

Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas
por: Ericson, Kajsa, et al.
Publicado: (2004)

Instability of CTG Repeats is Governed by the Position of a DNA Base Lesion through Base Excision Repair
por: Lai, Yanhao, et al.
Publicado: (2013)

Characterization and comparative sequence analysis of the DNA mismatch repair MSH2 and MSH7 genes from tomato
por: Tam, Sheh May, et al.
Publicado: (2009)

MSH6 syndrome
por: Suchy, Janina, et al.
Publicado: (2008)

Drugging DNA Damage Repair Pathways for Trinucleotide Repeat Expansion Diseases
por: Benn, Caroline L., et al.
Publicado: (2021)

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
por: Pritchard, Colin C., et al.
Publicado: (2014)

The properties of Msh2–Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair
por: Graham, William J., et al.
Publicado: (2018)

An Evaluation of the Immunohistochemical Expression of Mismatch Repair Proteins (MSH2, MSH6, MLH1, and PMS2) in Prostate Adenocarcinoma
por: Javeed, Saira, et al.
Publicado: (2022)

The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers
por: Lawes, D A, et al.
Publicado: (2005)

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
por: Martomo, Stella A., et al.
Publicado: (2004)

Mismatch Recognition by Saccharomyces cerevisiae Msh2-Msh6: Role of Structure and Dynamics
por: Li, Yan, et al.
Publicado: (2019)

The 26S proteasome drives trinucleotide repeat expansions
por: Concannon, Claire, et al.
Publicado: (2013)

NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair
por: Bone, K M, et al.
Publicado: (2015)

The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex
por: Acurzio, Basilia, et al.
Publicado: (2022)

MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions
por: Keogh, Norma, et al.
Publicado: (2017)

A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice
por: Maksimov, Mikhail O., et al.
Publicado: (2023)

Abnormal Base Excision Repair at Trinucleotide Repeats Associated with Diseases: A Tissue-Selective Mechanism
por: Goula, Agathi-Vasiliki, et al.
Publicado: (2013)

Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families
por: Thodi, Georgia, et al.
Publicado: (2010)

Mismatch Repair Proteins and Microsatellite Instability in Colorectal Carcinoma (MLH1, MSH2, MSH6 and PMS2): Histopathological and Immunohistochemical Study
por: Ismael, Nour El Hoda S., et al.
Publicado: (2017)

Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions
por: Debacker, Kim, et al.
Publicado: (2012)

RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility
por: Frizzell, Aisling, et al.
Publicado: (2014)

Structural Insights into Saccharomyces cerevisiae Msh4–Msh5 Complex Function Using Homology Modeling
por: Rakshambikai, Ramaswamy, et al.
Publicado: (2013)

Msh4 and Msh5 Function in SC-Independent Chiasma Formation During the Streamlined Meiosis of Tetrahymena
por: Shodhan, Anura, et al.
Publicado: (2014)

MSH2 and MLH1 testing
por: Kurzawski, Grzegorz, et al.
Publicado: (2008)

MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases
por: Clark, Nicole, et al.
Publicado: (2013)

The Tendency of Having MSH2 and MSH6 Microsatellite Instability among Clinicopathological Features in Patients with Colorectal Cancer
por: Arshita, Neni, et al.
Publicado: (2018)

Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses
por: Peng, Min, et al.
Publicado: (2014)

Trinucleotide repeat expansions catalyzed by human cell-free extracts
por: Stevens, Jennifer R, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_pfei8029m9sj1kssuai4idkvv4