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Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway
Since early oligomeric intermediates in amyloid assembly are often transient and difficult to distinguish, characterize and quantify, the mechanistic basis of the initiation of spontaneous amyloid growth is often opaque. We describe here an approach to the analysis of the Aβ aggregation mechanism th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996947/ https://www.ncbi.nlm.nih.gov/pubmed/27546208 http://dx.doi.org/10.1038/ncomms12419 |