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Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage
The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997427/ https://www.ncbi.nlm.nih.gov/pubmed/27556484 http://dx.doi.org/10.3390/nu8080514 |
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author | Kano, Mitsuyoshi Kubota, Norihiro Masuoka, Norie Hori, Tetsuji Miyazaki, Kouji Ishikawa, Fumiyasu |
author_facet | Kano, Mitsuyoshi Kubota, Norihiro Masuoka, Norie Hori, Tetsuji Miyazaki, Kouji Ishikawa, Fumiyasu |
author_sort | Kano, Mitsuyoshi |
collection | PubMed |
description | The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of isoflavones. The erythema intensity of dorsal skin was significantly higher in ovariectomized mice than in sham-operated mice (p < 0.05). The erythema intensity and epidermal thickness of dorsal skin were significantly lower in the fermented soymilk diet group than in the control diet group (each p < 0.05). Levels of cyclobutane pyrimidine dimers in dorsal skin were significantly lower in the fermented soymilk diet group than in the control group (p < 0.05). Serum and dorsal skin isoflavone concentrations were significantly higher in the fermented soymilk diet group than in the soymilk diet group (p < 0.05). These results indicate that oral administration of a fermented soymilk diet increases isoflavone concentrations in the blood and skin, effectively scavenging the reactive oxygen species generated by UV irradiation and exerting an estrogen-like activity, with a consequent protective effect on skin photodamage in hairless mice. |
format | Online Article Text |
id | pubmed-4997427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49974272016-08-26 Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage Kano, Mitsuyoshi Kubota, Norihiro Masuoka, Norie Hori, Tetsuji Miyazaki, Kouji Ishikawa, Fumiyasu Nutrients Article The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of isoflavones. The erythema intensity of dorsal skin was significantly higher in ovariectomized mice than in sham-operated mice (p < 0.05). The erythema intensity and epidermal thickness of dorsal skin were significantly lower in the fermented soymilk diet group than in the control diet group (each p < 0.05). Levels of cyclobutane pyrimidine dimers in dorsal skin were significantly lower in the fermented soymilk diet group than in the control group (p < 0.05). Serum and dorsal skin isoflavone concentrations were significantly higher in the fermented soymilk diet group than in the soymilk diet group (p < 0.05). These results indicate that oral administration of a fermented soymilk diet increases isoflavone concentrations in the blood and skin, effectively scavenging the reactive oxygen species generated by UV irradiation and exerting an estrogen-like activity, with a consequent protective effect on skin photodamage in hairless mice. MDPI 2016-08-20 /pmc/articles/PMC4997427/ /pubmed/27556484 http://dx.doi.org/10.3390/nu8080514 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kano, Mitsuyoshi Kubota, Norihiro Masuoka, Norie Hori, Tetsuji Miyazaki, Kouji Ishikawa, Fumiyasu Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage |
title | Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage |
title_full | Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage |
title_fullStr | Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage |
title_full_unstemmed | Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage |
title_short | Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage |
title_sort | oral administration of fermented soymilk products protects the skin of hairless mice against ultraviolet damage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997427/ https://www.ncbi.nlm.nih.gov/pubmed/27556484 http://dx.doi.org/10.3390/nu8080514 |
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