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Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage

The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of i...

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Autores principales: Kano, Mitsuyoshi, Kubota, Norihiro, Masuoka, Norie, Hori, Tetsuji, Miyazaki, Kouji, Ishikawa, Fumiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997427/
https://www.ncbi.nlm.nih.gov/pubmed/27556484
http://dx.doi.org/10.3390/nu8080514
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author Kano, Mitsuyoshi
Kubota, Norihiro
Masuoka, Norie
Hori, Tetsuji
Miyazaki, Kouji
Ishikawa, Fumiyasu
author_facet Kano, Mitsuyoshi
Kubota, Norihiro
Masuoka, Norie
Hori, Tetsuji
Miyazaki, Kouji
Ishikawa, Fumiyasu
author_sort Kano, Mitsuyoshi
collection PubMed
description The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of isoflavones. The erythema intensity of dorsal skin was significantly higher in ovariectomized mice than in sham-operated mice (p < 0.05). The erythema intensity and epidermal thickness of dorsal skin were significantly lower in the fermented soymilk diet group than in the control diet group (each p < 0.05). Levels of cyclobutane pyrimidine dimers in dorsal skin were significantly lower in the fermented soymilk diet group than in the control group (p < 0.05). Serum and dorsal skin isoflavone concentrations were significantly higher in the fermented soymilk diet group than in the soymilk diet group (p < 0.05). These results indicate that oral administration of a fermented soymilk diet increases isoflavone concentrations in the blood and skin, effectively scavenging the reactive oxygen species generated by UV irradiation and exerting an estrogen-like activity, with a consequent protective effect on skin photodamage in hairless mice.
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spelling pubmed-49974272016-08-26 Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage Kano, Mitsuyoshi Kubota, Norihiro Masuoka, Norie Hori, Tetsuji Miyazaki, Kouji Ishikawa, Fumiyasu Nutrients Article The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of isoflavones. The erythema intensity of dorsal skin was significantly higher in ovariectomized mice than in sham-operated mice (p < 0.05). The erythema intensity and epidermal thickness of dorsal skin were significantly lower in the fermented soymilk diet group than in the control diet group (each p < 0.05). Levels of cyclobutane pyrimidine dimers in dorsal skin were significantly lower in the fermented soymilk diet group than in the control group (p < 0.05). Serum and dorsal skin isoflavone concentrations were significantly higher in the fermented soymilk diet group than in the soymilk diet group (p < 0.05). These results indicate that oral administration of a fermented soymilk diet increases isoflavone concentrations in the blood and skin, effectively scavenging the reactive oxygen species generated by UV irradiation and exerting an estrogen-like activity, with a consequent protective effect on skin photodamage in hairless mice. MDPI 2016-08-20 /pmc/articles/PMC4997427/ /pubmed/27556484 http://dx.doi.org/10.3390/nu8080514 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kano, Mitsuyoshi
Kubota, Norihiro
Masuoka, Norie
Hori, Tetsuji
Miyazaki, Kouji
Ishikawa, Fumiyasu
Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage
title Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage
title_full Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage
title_fullStr Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage
title_full_unstemmed Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage
title_short Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage
title_sort oral administration of fermented soymilk products protects the skin of hairless mice against ultraviolet damage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997427/
https://www.ncbi.nlm.nih.gov/pubmed/27556484
http://dx.doi.org/10.3390/nu8080514
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