Analysis of gene repair tracts from Cas9/gRNA double-stranded breaks in the human CFTR gene

To maximise the efficiency of template-dependent gene editing, most studies describe programmable and/or RNA-guided endonucleases that make a double-stranded break at, or close to, the target sequence to be modified. The rationale for this design strategy is that most gene repair tracts will be very...

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Detalles Bibliográficos
Autores principales: Hollywood, Jennifer A., Lee, Ciaran M., Scallan, Martina F., Harrison, Patrick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997560/
https://www.ncbi.nlm.nih.gov/pubmed/27557525
http://dx.doi.org/10.1038/srep32230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997560/
https://www.ncbi.nlm.nih.gov/pubmed/27557525
http://dx.doi.org/10.1038/srep32230

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