Clomiphene and Its Isomers Block Ebola Virus Particle Entry and Infection with Similar Potency: Potential Therapeutic Implications

The 2014 outbreak of Ebola virus (EBOV) in Western Africa highlighted the need for anti-EBOV therapeutics. Clomiphene is a U.S. Food and Drug Administration (FDA)-approved drug that blocks EBOV entry and infection in cells and significantly protects EBOV-challenged mice. As provided, clomiphene is,...

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Detalles Bibliográficos
Autores principales: Nelson, Elizabeth A., Barnes, Alyson B., Wiehle, Ronald D., Fontenot, Gregory K., Hoenen, Thomas, White, Judith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997570/
https://www.ncbi.nlm.nih.gov/pubmed/27490565
http://dx.doi.org/10.3390/v8080206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997570/
https://www.ncbi.nlm.nih.gov/pubmed/27490565
http://dx.doi.org/10.3390/v8080206

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