Markov chain Monte Carlo and expectation maximization approaches for estimation of haplotype frequencies for multiply infected human blood samples

BACKGROUND: Haplotypes are important in anti-malarial drug resistance because genes encoding drug resistance may accumulate mutations at several codons in the same gene, each mutation increasing the level of drug resistance and, possibly, reducing the metabolic costs of previous mutation. Patients o...

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Detalles Bibliográficos
Autores principales: Ken-Dror, Gie, Hastings, Ian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997664/
https://www.ncbi.nlm.nih.gov/pubmed/27557806
http://dx.doi.org/10.1186/s12936-016-1473-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997664/
https://www.ncbi.nlm.nih.gov/pubmed/27557806
http://dx.doi.org/10.1186/s12936-016-1473-5

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