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The multi-omic landscape of transcription factor inactivation in cancer
BACKGROUND: Hypermethylation of transcription factor promoters bivalently marked in stem cells is a cancer hallmark. However, the biological significance of this observation for carcinogenesis is unclear given that most of these transcription factors are not expressed in any given normal tissue. MET...
Autores principales: | Teschendorff, Andrew E., Zheng, Shijie C., Feber, Andy, Yang, Zhen, Beck, Stephan, Widschwendter, Martin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997779/ https://www.ncbi.nlm.nih.gov/pubmed/27562343 http://dx.doi.org/10.1186/s13073-016-0342-8 |
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