Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System

The transmissible spongiform encephalopathies are fatal neurodegenerative disorders characterized by the misfolding of the native cellular prion protein (PrP(C)) into the accumulating, disease-associated isoform (PrP(Sc)). Despite extensive research into the inhibition of prion accumulation, no effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Dinkel, Kelcey D., Stanton, James B., Boykin, David W., Stephens, Chad E., Madsen-Bouterse, Sally A., Schneider, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997874/
https://www.ncbi.nlm.nih.gov/pubmed/27381401
http://dx.doi.org/10.1128/AAC.00811-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997874/
https://www.ncbi.nlm.nih.gov/pubmed/27381401
http://dx.doi.org/10.1128/AAC.00811-16

Ejemplares similares