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Antiprion Activity of DB772 and Related Monothiophene- and Furan-Based Analogs in a Persistently Infected Ovine Microglia Culture System

The transmissible spongiform encephalopathies are fatal neurodegenerative disorders characterized by the misfolding of the native cellular prion protein (PrP(C)) into the accumulating, disease-associated isoform (PrP(Sc)). Despite extensive research into the inhibition of prion accumulation, no effe...

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Detalles Bibliográficos
Autores principales:	Dinkel, Kelcey D., Stanton, James B., Boykin, David W., Stephens, Chad E., Madsen-Bouterse, Sally A., Schneider, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997874/ https://www.ncbi.nlm.nih.gov/pubmed/27381401 http://dx.doi.org/10.1128/AAC.00811-16

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